Cajal bodies: a long history of discovery.

@article{Cioce2005CajalBA,
  title={Cajal bodies: a long history of discovery.},
  author={M. Cioce and A. Lamond},
  journal={Annual review of cell and developmental biology},
  year={2005},
  volume={21},
  pages={
          105-31
        }
}
  • M. Cioce, A. Lamond
  • Published 2005
  • Biology, Medicine
  • Annual review of cell and developmental biology
This review surveys what is known about the structure and function of the subnuclear domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we provide an overview of homologous CB structures in other organisms. We discuss the protein and RNA components of CBs, including factors recently found to associate in a cell cycle-dependent fashion or under specific metabolic or stress conditions. We also consider the dynamic properties of both CBs and their molecular… Expand
Phosphorylation and the Cajal body: modification in search of function.
  • M. Hebert
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 2010
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The goal of this review is to demonstrate the need for a concerted effort towards elucidating the functional consequence of phosphorylation on CB formation and activity. Expand
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The recent identification of novel markers for CBs in both Drosophila and Arabidopsis not only lays to rest questions about the evolutionary conservation of these nuclear suborganelles, but also should enable forward genetic screens for the identification of new components and pathways involved in their assembly, maintenance and function. Expand
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Since its discovery over 100 years ago, the nucleoplasmic Cajal body (CB) has been linked to the nucleolus by both physical proximity and shared components. The CB contains factors necessary forExpand
Cajal bodies in neurons
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It is shown that CBs are particularly prominent in neurons, where they frequently associate with the nucleolus, and their number dynamically accommodates to support the high neuronal demand for splicing and ribosome biogenesis required for sustaining metabolic and bioelectrical activity. Expand
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TLDR
This work proposes an additional layer of complexity, whereby a set of pre-existing substructures can be integrated into mature CBs, and proposes this as a multi-seeding model of CB assembly. Expand
The Cajal body.
  • G. Morris
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2008
TLDR
Over the last 10 years, research into the function of Cajal bodies has been greatly stimulated by the discovery that SMN, the protein deficient in the inherited neuromuscular disease, spinal muscular atrophy, is an essential role in the assembly of spliceosomal U snRNPs in the cytoplasm and their delivery to the Cjal body in the nucleus. Expand
Cajal bodies and histone locus bodies: Molecular composition and function
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Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines
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The data support a model whereby coilin is the target of an uncharacterized signal transduction cascade that responds to the increased transcription and snRNP demands found in transformed cells. Expand
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References

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TLDR
The results point to a model whereby phosphorylation of the coilin C-terminus regulates the availability of the N-terminal self-interaction domain, which must reside in the nucleus, as constructs lacking critical nuclear localization sequences fail to form foci in the cytoplasm. Expand
In vivo kinetics of Cajal body components
TLDR
Photobleaching and fluorescence resonance energy transfer experiments demonstrate that coilin and SMN can interact within CBs, but their interaction is not the major determinant of their residence times, suggesting that CBs and gems are kinetically independent structures. Expand
Self-association of coilin reveals a common theme in nuclear body localization.
TLDR
It is found that coilin, the marker protein for Cajal bodies (coiled bodies, CBs), is a self-interacting protein, and the domain responsible for this activity is mapped to the amino-terminus, together with a nuclear localization signal, which is necessary and sufficient for localization to CBs. Expand
Identification of a new coiled body component.
TLDR
P pigpen, a new member of the EWS family of proteins, is identified as a second protein enriched in coiled bodies, and its nuclear compartment is characterized and its reorganization during mitosis is described. Expand
In Vivo Analysis of Cajal Body Movement, Separation, and Joining in Live Human Cells
TLDR
An unexpectedly high level of movement and interactions of nuclear bodies in human cells is revealed and it is suggested that these movements may be driven, at least in part, by regulated mechanisms. Expand
Nopp140 Functions as a Molecular Link Between the Nucleolus and the Coiled Bodies
Coiled bodies are small nuclear organelles that are highly enriched in small nuclear RNAs, and that have long been thought to be associated with the nucleolus. Here we use mutational analysis,Expand
Cajal Body dynamics and association with chromatin are ATP-dependent
TLDR
It is shown that CB mobility is described by anomalous diffusion and that bodies alternate between association with chromatin and diffusion within the interchromatin space, suggesting that a novel mechanism governs CB, and possibly other, nuclear body dynamics. Expand
Targeting SMN to Cajal bodies and nuclear gems during neuritogenesis
TLDR
It is shown that the number and composition of the nuclear subdomains called Cajal bodies and gems changes during the course of N-ras-induced neuritogenesis in the PC12-derived cell line UR61, and that gems clearly represent a distinct category of nuclear body. Expand
Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments
TLDR
Spatial organization of U3 maturation appears to be conserved across evolution, and involves specialized and related nuclear compartments, the nucleolus/nucleolar body in yeast and Cajal bodies in higher eukaryotes. Expand
RNA-mediated interaction of Cajal bodies and U2 snRNA genes
TLDR
Analysis of expression and subcellular localization of stably transfected artificial arrays of U2 snRNA genes provides significant insight into the mechanism of CB interaction with snRNA loci, strengthening the putative role for this nuclear suborganelle in snRNP biogenesis. Expand
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