Cajal-Retzius cells fail to trigger the developmental expression of the Cl- extruding co-transporter KCC2.

@article{Pozas2008CajalRetziusCF,
  title={Cajal-Retzius cells fail to trigger the developmental expression of the Cl- extruding co-transporter KCC2.},
  author={Esther Pozas and Sonia Paco and Eduardo Soriano and F J Samino Aguado},
  journal={Brain research},
  year={2008},
  volume={1239},
  pages={85-91}
}
Cajal-Retzius (CR) cells are transient neurons of the developing cerebral cortex that play a pivotal role in the lamination and construction of neural circuits. One physiological feature of CR cells is the failure to switch GABAergic transmission from excitation to inhibition. To examine the mechanisms underlying the persistence of the depolarizing action of GABA we analyzed the mRNA expression of the K+/Cl- co-transporter type 2 (KCC2) in mouse CR by in situ hybridization. During the second… CONTINUE READING
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