Caged phospho-amino acid building blocks for solid-phase peptide synthesis.

  title={Caged phospho-amino acid building blocks for solid-phase peptide synthesis.},
  author={Deborah M Rothman and M Eugenio V{\'a}zquez and Elizabeth Maura Vogel and Barbara Imperiali},
  journal={The Journal of organic chemistry},
  volume={68 17},
Three 1-(2-nitrophenyl)ethyl-caged phospho-amino acids have been synthesized for use in standard N(alpha)-fluorenylmethoxycarbonyl-based solid-phase peptide synthesis (SPPS). The most common naturally occurring phospho-amino acids, serine, threonine, and tyrosine, were prepared as protected caged building blocks by modification with a unique phosphitylating reagent. In previous work, caged phospho-peptides were made using an interassembly approach (Rothman, D. M.; Vazquez, M. E.; Vogel, E. M… CONTINUE READING

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