CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling.

@article{Handa2007CagAPO,
  title={CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling.},
  author={Osamu Handa and Yuji Naito and Toshikazu Yoshikawa},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 11},
  pages={1697-702}
}
Epidemiological study has shown strong correlation between the Helicobacter pylori (H. pylori) infection and gastric carcinogenesis. However, the mechanism by which H. pylori induces gastric carcinogenesis is not known. In this review, we focused on the product of cytotoxin-associated gene A (CagA), one of the important virulence factors of H. pylori. H. pylori injects CagA protein into the host gastric epithelial cells through its needle-like structure, type IV secretion system. Injected CagA… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 45 references

Cytotoxin-associated gene product A of Helicobacter pylori induced cellular response in rat gastric epithelial cell

O Handa, Y Naito, +3 authors T Takagi
Digestion • 2006
View 2 Excerpts

Helicobacter pylori Cag A induces mitochondriadependent production of reactive oxygen species in gastric epithelial cell

O Handa, Y Naito, +3 authors T Takagi
Gastroenterology • 2006
View 2 Excerpts

Oxidative stress in Helicobacter pyloriassociated gastroduodenal disease

H Suzuki, T. Hibi
J Clin Biochem Nutrit 2006;39:56–63 • 2006
View 1 Excerpt

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