Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses.

@article{Kulkarni2015CaffeoylGF,
  title={Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses.},
  author={Roshan Rajan Kulkarni and W Lee and Tae Su Jang and Jungin Lee and Soyoung Kwak and Mi seon Park and H J Lee and Jong-Sup Bae and MinKyun Na},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 22},
  pages={
          5367-71
        }
}
Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of… CONTINUE READING
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