Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.

@article{Sawynok2008CaffeineRA,
  title={Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.},
  author={Jana Sawynok and Allison R Reid and Bertil B. Fredholm},
  journal={Neuroscience letters},
  year={2008},
  volume={440 2},
  pages={181-4}
}
Amitriptyline is used to treat neuropathic pain in humans. It produces antinociception in several animal models of pain, and this effect is blocked by methylxanthine adenosine receptor antagonists which implicates adenosine it its actions. Here, the antinociceptive effect of amitriptyline, and the ability of caffeine to reverse it, were examined using the… CONTINUE READING