Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis.

Abstract

OBJECTIVE Impaired mitochondrial function is a potential cause of sepsis-associated myocardial depression. Cytochrome oxidase (CcOX), the terminal oxidase of the electron transport chain, is inhibited in the septic heart. Caffeine increases CcOX activity by increasing cyclic adenosine monophosphate and protein kinase A activity. We hypothesized that… (More)
DOI: 10.1097/CCM.0b013e31819cecd6

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Cite this paper

@article{Verma2009CaffeineRM, title={Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis.}, author={Richa Verma and Zhishan Huang and Clifford S. Deutschman and Richard J Levy}, journal={Critical care medicine}, year={2009}, volume={37 4}, pages={1397-402} }