• Chemistry, Medicine
  • Published in
    The Journal of pharmacology…
    1989

Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine.

@article{Brown1989CaffeinePT,
  title={Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine.},
  author={Norman S. Brown and John Norman Porter and David E. Ryder and Robert A. Branch},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={256 1},
  pages={
          56-61
        }
}
In the rat and dog, exogenous adenosine inhibits renin release and adenosine receptor blockade augments stimulated renin release, suggesting that endogenous adenosine contributes to the regulation of renin release. The present study examines the role of endogenous adenosine in the regulation of renin in humans. The ability of the adenosine receptor blocker, caffeine, to augment renin release in response to the vasodilator, diazoxide, has been investigated in eight normal subjects in a double… CONTINUE READING