Caffeine potentiates the discriminative-stimulus effects of nicotine in rats

  title={Caffeine potentiates the discriminative-stimulus effects of nicotine in rats},
  author={Maciej Gasior and Maria Jaszyna and Patrik Munzar and Jeffrey M. Witkin and Steven R. Goldberg},
Rationale. Caffeine and nicotine are the main psychoactive ingredients of coffee and tobacco, respectively, with a high frequency of concurrent use in humans. Objectives. The aim of the present study was to examine the interaction of caffeine and nicotine in rats trained to discriminate nicotine from saline. Methods. Two groups of male Sprague-Dawley rats (n=8 per group) were trained to discriminate 0.4 mg/kg nicotine, SC, from saline under a fixed ratio schedule of food presentation. One group… CONTINUE READING

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