Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.

@article{Geraets2006CaffeineMA,
  title={Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.},
  author={Liesbeth Geraets and Harald J J Moonen and Emiel F. M. Wouters and Aalt Bast and Geja J. Hageman},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 7},
  pages={902-10}
}
The activity of the nuclear enzyme poly(ADP-ribose)polymerase-1 (E.C.2.4.2.30), which is highly activated by DNA strand breaks, is associated with the pathophysiology of both acute as well as chronic inflammatory diseases. PARP-1 overactivation and the subsequent extensive turnover of its substrate NAD+ put a large demand on mitochondrial ATP-production. Furthermore, due to its reported role in NF-kappaB and AP-1 mediated production of pro-inflammatory cytokines, PARP-1 is considered an… CONTINUE READING
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