Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.

  title={Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity.},
  author={Bettina A. Hamelin and Ke-hui Xu and Francesca Valle and Lynn J Manseau and Michael G. Richer and Marc Lebel},
  journal={Clinical pharmacology and therapeutics},
  volume={56 5},
STUDY OBJECTIVE To characterize the activities of the P450 mixed-function oxidase CYP1A2 as well as the cytosolic enzymes N-acetyltransferase and xanthine oxidase using caffeine as a probe in children with cystic fibrosis compared to age-matched healthy control subjects. METHODS After administration of caffeine (cola beverage) to 12 children with cystic fibrosis (age range, 5 to 11 years) and 12 healthy control subjects (age range, 5 to 12 years), urine was collected for 4 hours. Caffeine… CONTINUE READING

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