Caffeine-mediated release of alpha-radiation-induced G2 arrest increases the yield of chromosome aberrations.

@article{LckeHuhle1983CaffeinemediatedRO,
  title={Caffeine-mediated release of alpha-radiation-induced G2 arrest increases the yield of chromosome aberrations.},
  author={Christine L{\"u}cke-Huhle and Ludwig Hieber and R D Wegner},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1983},
  volume={43 2},
  pages={123-32}
}
Severe and partly irreversible G2 arrest caused by americium-241 alpha-particles in Chinese hamster V79 cells acted as a competing process to the yield of detectable aberrant mitoses at metaphase. With increasing dose of alpha-radiation an increasing fraction of cells was irreversibly arrested in G2 with the consequence of interphase death before the first post-irradiation mitosis. This irreversible G2 arrest (demonstrated by flow cytofluorometry and mitotic indices) could be overcome by adding… CONTINUE READING

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