Caffeine intensities taste of certain sweeteners: Role of adenosine receptor

@article{Schiffman1986CaffeineIT,
  title={Caffeine intensities taste of certain sweeteners: Role of adenosine receptor},
  author={Susan S. Schiffman and C. D{\'i}az and Timothy G. Beeker},
  journal={Pharmacology Biochemistry and Behavior},
  year={1986},
  volume={24},
  pages={429-432}
}
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Recent insights into the mechanisms of taste transduction and modulation
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Chronic administration of caffeine alters acesulfame-K intake and features of fungiform taste buds in mice
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It is found that following a 21-day administration of caffeine, mice showed increased behavioural responses to sweet stimuli (acesulfame-K solution), and chronic caffeine treatment evidently decreased the maximal cross-sectional area and height of the longitudinal axis of fungiform taste buds.
Dual actions of caffeine on voltage-dependent currents and intracellular calcium in taste receptor cells.
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Caffeine's dual actions on voltage-activated ionic currents and intracellular calcium levels suggest that a single taste stimulus, caffeine, utilizes multiple transduction mechanisms.
Caffeine ingested under natural conditions does not alter taste intensity
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THE IMPORTANCE OF CAFFEINE AS A FLAVOR COMPONENT IN BEVERAGES
Caffeine contributes to the flavor profiles of beverage and food products, and other bitter compounds, such as quinine, cannot replicate caffeine's bitterness. Research also has indicated caffeine's…
A2BR Adenosine Receptor Modulates Sweet Taste in Circumvallate Taste Buds
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This study identified a novel regulator of sweet taste, the A2BR, which functions to potentiate sweet responses in posterior lingual taste fields in mice with significantly reduced responses to both sucrose and synthetic sweeteners.
Adenosine antagonists as potential therapeutic agents
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This work reports an experiment designed to distinguish between bitter–sweet and conformationally defined glycoside, methyl-α-D-mannopyranoside, using a typical bitter– Sweet–Bitter sugar molecule and its simple derivatives, and shows that neither response can be altered by exhaustive stepwise purification of such compounds.
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Adenosine may be an important modulator of mast cell function in complex tissues and that part of the pharmacologic action of theophylline in human bronchial asthma may be through inhibition of adenosine binding, rather than direct effects on cyclic AMP metabolism.
Qualitative differences among sweeteners
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