Caffeine intensities taste of certain sweeteners: Role of adenosine receptor

@article{Schiffman1986CaffeineIT,
  title={Caffeine intensities taste of certain sweeteners: Role of adenosine receptor},
  author={Susan S. Schiffman and C. D{\'i}az and Timothy G. Beeker},
  journal={Pharmacology Biochemistry and Behavior},
  year={1986},
  volume={24},
  pages={429-432}
}
Caffeine May Reduce Perceived Sweet Taste in Humans, Supporting Evidence That Adenosine Receptors Modulate Taste.
TLDR
This work validates earlier observations in rodents in a human population by finding that caffeine, a powerful antagonist for adenosine receptors, can inhibit the perception of sweet taste in humans.
Caffeine taste test for panic disorder: Adenosine receptor supersensitivity
Chronic administration of caffeine alters acesulfame-K intake and features of fungiform taste buds in mice
TLDR
It is found that following a 21-day administration of caffeine, mice showed increased behavioural responses to sweet stimuli (acesulfame-K solution), and chronic caffeine treatment evidently decreased the maximal cross-sectional area and height of the longitudinal axis of fungiform taste buds.
Dual actions of caffeine on voltage-dependent currents and intracellular calcium in taste receptor cells.
TLDR
Caffeine's dual actions on voltage-activated ionic currents and intracellular calcium levels suggest that a single taste stimulus, caffeine, utilizes multiple transduction mechanisms.
Caffeine ingested under natural conditions does not alter taste intensity
  • D. Mela
  • Biology
    Pharmacology Biochemistry and Behavior
  • 1989
THE IMPORTANCE OF CAFFEINE AS A FLAVOR COMPONENT IN BEVERAGES
Caffeine contributes to the flavor profiles of beverage and food products, and other bitter compounds, such as quinine, cannot replicate caffeine's bitterness. Research also has indicated caffeine's
A2BR Adenosine Receptor Modulates Sweet Taste in Circumvallate Taste Buds
TLDR
This study identified a novel regulator of sweet taste, the A2BR, which functions to potentiate sweet responses in posterior lingual taste fields in mice with significantly reduced responses to both sucrose and synthetic sweeteners.
Adenosine antagonists as potential therapeutic agents
...
...

References

SHOWING 1-10 OF 17 REFERENCES
Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.
TLDR
Application of amiloride to the human tongue reduced the taste intensity of sodium and lithium salts and of sweeteners ranging widely in chemical structure, consistent with the position that an amILoride-sensitive transport mechanism is involved in taste perception of sodium, lithium, and saccharides.
Sweet taste receptor mechanisms.
  • M. Sato
  • Biology
    The Japanese journal of physiology
  • 1985
TLDR
A recent attempt to isolate a protein from monkey tongues revealed the presence of a thaumatin-binding protein of M.W. of approximately 50,000, predominantly found in taste papillae, with lesser amounts found in non-taste tissue.
Subclasses of external adenosine receptors.
  • C. Londos, D. Cooper, J. Wolff
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1980
TLDR
The potency of adenosine is intermediate between the potencies of these two analogs and is maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis.
Evidence for the proximity of sweet and bitter receptor sites
TLDR
This work reports an experiment designed to distinguish between bitter–sweet and conformationally defined glycoside, methyl-α-D-mannopyranoside, using a typical bitter– Sweet–Bitter sugar molecule and its simple derivatives, and shows that neither response can be altered by exhaustive stepwise purification of such compounds.
ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS
Abstract— In cell cultures of glial character derived from perinatal mouse brain adenosine elicits two effects. (a) At submicromolar concentrations It inhibits the increase in the intracellular level
Potentiation of mast cell mediator release by adenosine.
TLDR
Adenosine may be an important modulator of mast cell function in complex tissues and that part of the pharmacologic action of theophylline in human bronchial asthma may be through inhibition of adenosine binding, rather than direct effects on cyclic AMP metabolism.
Qualitative differences among sweeteners
...
...