Caffeine inhibits the checkpoint kinase ATM

@article{Blasina1999CaffeineIT,
  title={Caffeine inhibits the checkpoint kinase ATM},
  author={Alessandra Blasina and Brendan D. Price and Gaetan A. Turenne and Clare H. McGowan},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={1135-1138}
}
The basis of many anti-cancer therapies is the use of genotoxic agents that damage DNA and thus kill dividing cells. Agents that cause cells to override the DNA-damage checkpoint are predicted to sensitize cells to killing by genotoxic agents. They have therefore been sought as adjuncts in radiation therapy and chemotherapy. One such compound, caffeine, uncouples cell-cycle progression from the replication and repair of DNA [1] [2]. Caffeine therefore servers as a model compound in establishing… CONTINUE READING
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