Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.

  title={Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.},
  author={Terry E. Graham and Premila Sathasivam and Mary Rowland and Natasha Marko and Felicia A. Greer and Danielle S. Battram},
  journal={Canadian journal of physiology and pharmacology},
  volume={79 7},
We tested the hypothesis that caffeine ingestion results in an exaggerated response in blood glucose and (or) insulin during an oral glucose tolerance test (OGTT). Young, fit adult males (n = 18) underwent 2 OGTT. The subjects ingested caffeine (5 mg/kg) or placebo (double blind) and 1 h later ingested 75 g of dextrose. There were no differences between the fasted levels of serum insulin, C peptide, blood glucose, or lactate and there were no differences within or between trials in these… 
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A nutrition and exercise intervention improved, whereas caffeine ingestion impaired, insulin-glucose homeostasis in obese men, consistent with previous findings that caffeine ingestion contributes to insulin resistance.
Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males
Although 14 d of caffeine consumption by previously caffeine-naive subjects reduced its impact on glucose homeostasis, carbohydrate metabolism remained disrupted and caffeine concentrations in serum NEFA and plasma adrenaline concentrations were decreased.
Effect of Caffeine on Plasma Glucose and Insulin Response to Mixed Meal Tolerance Test in Type II Diabetes
It may be concluded that acute administration of caffeine plus carbohydrate impaired post-prandial glucose metabolism and insulin responses could have implication for the management of type II diabetic patients.
Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus.
Caffeine impaired insulin sensitivity in women with GDM, according to a 2-hour oral glucose tolerance test conducted in a double-blind randomized crossover study.
Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia.
It is shown that acute Caf ingestion does not increase epinephrine concentration or impair glucose tolerance in TP, and this lack of a Caf effect may be due to the low epinphrine concentration that remained unchanged throughout all experiments.
Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males
Co-ingestion of CC with one meal resulted in insulin insensitivity during the postprandial phase of a second meal in the absence of further CC ingestion, suggesting that CC may play a role in daily glycaemic management.
An oral lipid challenge and acute intake of caffeinated coffee additively decrease glucose tolerance in healthy men.
Oral consumption of lipids and caffeinated coffee can independently and additively decrease glucose tolerance and could explain at least in part this impaired glucose homeostasis.
Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training.
Caffeine consumption is associated with a substantial reduction in insulin-mediated glucose uptake independent of obesity, type 2 diabetes, and chronic exercise.
Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women.
Results showed that caffeine ingestion disrupted insulin sensitivity in a dose-dependent fashion beginning at very low doses (0-1 mg·kg(-1) BW) in both healthy men and women.
The effect of caffeine on glucose kinetics in humans – influence of adrenaline
It is concluded that adrenaline alone does not account for the effects of caffeine and additional mechanisms must be involved.