• Chemistry, Medicine
  • Published in
    Journal of applied toxicology…
    2012
  • DOI:10.1002/jat.1698

Caffeine induction of sulfotransferases in rat liver and intestine.

@article{Zhou2012CaffeineIO,
  title={Caffeine induction of sulfotransferases in rat liver and intestine.},
  author={Tianyan Zhou and Yue Chen and Chaoqun Huang and Guangping Chen},
  journal={Journal of applied toxicology : JAT},
  year={2012},
  volume={32 10},
  pages={
          804-9
        }
}
Sulfotransferases (SULTs) are important phase II drug-metabolizing enzymes. Regulation of SULTs by hormones and other endogenous molecules is relatively well understood, while xenobiotic induction of SULTs is not well studied. Caffeine is one of the most widely consumed psychoactive substances. However, SULT regulation by caffeine has not been reported. In this report, male and female rats were treated with different oral doses of caffeine (2, 10, 50 mg kg⁻¹ per day) for 7 days. Western blot… CONTINUE READING

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