Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.

  title={Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.},
  author={Shinji Saiki and Yukiko Sasazawa and Yoko Imamichi and Sumihiro Kawajiri and Takahiro Fujimaki and Isei Tanida and Hiroki Kobayashi and Fumiaki Sato and Shigeto Sato and Ken-ichi Ishikawa and Masaya Imoto and Nobutaka Hattori},
  volume={7 2},
Caffeine is one of the most frequently ingested neuroactive compounds. All known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction. It is currently unknown whether caffeine-induced apoptosis is associated with other cell death mechanisms, such as autophagy. Herein we show that caffeine increases both the levels of microtubule-associated protein 1 light chain 3-II and the number of autophagosomes, through the use of western blotting, electron… CONTINUE READING
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