Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.

@article{John1991CaffeineinducedCI,
  title={Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.},
  author={G. W. John and E. Fabr{\`e}gues and M. Kamal and R. Massingham},
  journal={European journal of pharmacology},
  year={1991},
  volume={196 3},
  pages={
          307-12
        }
}
  • G. W. John, E. Fabrègues, +1 author R. Massingham
  • Published 1991
  • Chemistry, Medicine
  • European journal of pharmacology
  • Caffeine (1-60 mM) induced concentration-dependent, endothelium-independent phasic contractile responses in isolated rabbit renal artery ring preparations. For concentrations of caffeine over 2 mM, responses were mainly the result of intracellular calcium ion mobilization since they were relatively resistant to removal of calcium ions from the bathing medium. The L-type slow calcium channel blocker, nifedipine (10 microM), had no effect and high concentrations of verapamil and diltiazem (10-30… CONTINUE READING