Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells

@article{Dragievi2012CaffeineIM,
  title={Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells},
  author={N. Dragi{\vc}evi{\'c} and Vedad Delic and C. Cao and Neil Copes and P. Bradshaw},
  journal={Neuropharmacology},
  year={2012},
  volume={63},
  pages={1368-1379}
}
Caffeine and melatonin have been shown to protect the Swedish mutant amyloid precursor protein (APP(sw)) transgenic mouse model of Alzheimer's disease from cognitive dysfunction. But their mechanisms of action remain incompletely understood. These Alzheimer's mice have extensive mitochondrial dysfunction, which likely contributes to their cognitive decline. To further explore the mechanism through which caffeine and melatonin protect cognitive function in these mice, we monitored the function… Expand
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