Caffeine disposition after oral doses

@article{Bonati1982CaffeineDA,
  title={Caffeine disposition after oral doses},
  author={M. Bonati and R. Latini and F. Galletti and J. F. Young and G. Tognoni and S. Garattini},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1982},
  volume={32}
}
Caffeine (TMX) disposition was studied in men after 1, 5, and 10 mg/kg in water, as mocha coffee (1.54 mg/kg) and as a soft drink (0.22 mg/kg). TMX and its metabolites were analyzed in plasma and urine by high‐pressure liquid chromatography. The design permitted confirmation of most of the partial results in various experimental settings and contributed new data on the metabolic disposition of TMX, with specific reference to the main dimethylxanthine metabolite found in plasma, paraxanthine (1… Expand
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