• Corpus ID: 2114727

Caffeine can override the S-M checkpoint in fission yeast.

@article{Wang1999CaffeineCO,
  title={Caffeine can override the S-M checkpoint in fission yeast.},
  author={S W Wang and Chris J. Norbury and Adrian L. Harris and Takashi Toda},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 6)},
  pages={
          927-37
        }
}
The replication checkpoint (or 'S-M checkpoint') control prevents progression into mitosis when DNA replication is incomplete. Caffeine has been known for some time to have the capacity to override the S-M checkpoint in animal cells. We show here that caffeine also disrupts the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. By contrast, no comparable effects of caffeine on the S. pombe DNA damage checkpoint were seen. S. pombe cells arrested in early S phase and then exposed to… 

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