Caffeine attenuates CNS oxygen toxicity in rats

@article{Bitterman1995CaffeineAC,
  title={Caffeine attenuates CNS oxygen toxicity in rats},
  author={Noemi Bitterman and Shlomit Schaal},
  journal={Brain Research},
  year={1995},
  volume={696},
  pages={250-253}
}
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17 Citations
Background Citations
4

17 Citations

Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7.
TLDR
The gradual increase in seizure latency with increasing MK-801 doses suggests involvement of an additional factor probably related to the drug's anticonvulsive effect.
Role of cerebral blood flow in seizures from hyperbaric oxygen exposure
Caffeine protects neuronal cells against injury caused by hyperoxia in the immature brain.
[Influence of acetazolamide given intraperitoneally on the latency to hyperbaric oxygen-induced convulsion of rats.].
TLDR
It is suggested that acetazolamide which dilates the brain arterioles can obviously shorten the latency of hyperbaric oxygen-induced convulsion and aggravate the oxidation of the brain.
[Effect of acetazolamide on the latency of hyperbaric oxygen-induced convulsion].
TLDR
It is suggested that acetazolamide which dilates the brain arteriolar obviously shortens the latency of hyperbaric oxygen-induced convulsion, and that acetAZolamide Dilates the vessels and increases the supply of the oxygen breaking into the brain tissues and aggravates the oxidation.
Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures.
  • E. Manning
  • Medicine
    Aerospace medicine and human performance
  • 2016
TLDR
The mounting scientific evidence and apparent increase in the number of hyperbaric O2 treatments demonstrate a need for further study in the near future.
Attenuation of Cerebral Oxygen Toxicity by Sound Conditioning
  • A. Shupak, D. Tal, H. Pratt, Z. Sharoni, A. Hochman
  • Biology, Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2004
TLDR
The data show that sound conditioning prolongs the latency to oxygen-induced convulsions, and this effect was not accompanied by significant changes in whole-brain antioxidant enzyme activity or the magnitude of lipid peroxidation.
Changes in nitric oxide production and cerebral blood flow before development of hyperbaric oxygen-induced seizures in rats
CNS oxygen toxicity.
  • N. Bitterman
  • Medicine
    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
  • 2004
This short manuscript will briefly present our current knowledge about CNS oxygen toxicity: the clinical manifestations, descriptions and incidence of symptoms, and the time – duration relationship…
The intravenous perfluorocarbon emulsion Oxycyte does not increase hyperbaric oxygen-related seizures in a non-sedated swine model
TLDR
This finding demonstrates the safety of PFC use in conjunction with recompression therapy to treat DCS, and does not decrease seizure latency or increase duration on initial HBO exposure or after 24 h.
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References

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Statistical approach to the analysis of sensitivity to CNS oxygen toxicity in rats.
TLDR
Transformations of the latent period data were found to enhance normality, and the speed of appearance of the discharges in the EEG seems to be a simple, useful index for CNS oxygen toxicity in rats.
Caffeine Blocks Absence Seizures in the Tottering Mutant Mouse
TLDR
Caffeine injected intra‐peritoneally at the fourth hour of 8‐h recording sessions significantly decreased seizure incidence as compared with control saline injections, and another central nervous system (CNS) stimulating drug, amphetamine, under identical conditions failed to decrease seizure incidence in this mutant.
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
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Free radical generation in the brain precedes hyperbaric oxygen-induced convulsions.
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TLDR
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Adenosine deaminase reduces hypoxic and hypercapnic dilatation of rat pial arterioles: evidence for mediation by adenosine
The effect of carbon dioxide on the diameter of brain capillaries
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