Caffeine attenuates CNS oxygen toxicity in rats

@article{Bitterman1995CaffeineAC,
  title={Caffeine attenuates CNS oxygen toxicity in rats},
  author={N. Bitterman and S. Schaal},
  journal={Brain Research},
  year={1995},
  volume={696},
  pages={250-253}
}
We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may… Expand
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