Caffeine as a psychomotor stimulant: mechanism of action

@article{Fisone2003CaffeineAA,
  title={Caffeine as a psychomotor stimulant: mechanism of action},
  author={Gilberto Fisone and Anders Borgkvist and Alessandro Usiello},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2003},
  volume={61},
  pages={857-872}
}
The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which depend on its ability to reduce adenosine transmission in the brain. Adenosine A1 and A2A receptors are expressed in the basal ganglia, a group of structures involved in various aspects of motor control. Caffeine acts as an antagonist to both types of receptors. Increasing evidence indicates that the psychomotor stimulant effect of caffeine is generated by affecting a particular group of projection… 
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