Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements.

@article{Tang1994CaffeineAA,
  title={Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements.},
  author={B. K. Tang and Ying Zhou and Dezso Kadar and Werner Kalow},
  journal={Pharmacogenetics},
  year={1994},
  volume={4 3},
  pages={117-24}
}
Two established caffeine-based urinary methods for measuring CYP1A2 activity were compared with each other, and also with the systemic clearance of caffeine which served as a standard of reference for such activity. Following a standardized dose, caffeine (137X) and its metabolites were measured in urine and plasma of 39 healthy subjects. The measurements allowed determinations of: (1) systemic caffeine clearance (CL(caff)); (2) the caffeine metabolite ratio (AFMU + 1X + 1U)/17U determined in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…