Caffeine and uric acid mediate glutathione synthesis for neuroprotection

@article{Aoyama2011CaffeineAU,
  title={Caffeine and uric acid mediate glutathione synthesis for neuroprotection},
  author={Koji Aoyama and Nobuko Matsumura and Masahiko Watabe and F. Wang and Kazue Kikuchi-Utsumi and Toshio Nakaki},
  journal={Neuroscience},
  year={2011},
  volume={181},
  pages={206-215}
}
Several lines of epidemiological studies have indicated that caffeine consumption and plasma uric acid (UA) level were negatively correlated with the incidence of some neurodegenerative diseases. We report here a novel mechanism by which these purine derivatives increase neuronal glutathione (GSH) synthesis. Intraperitoneal injection of caffeine or UA into male C57BL/6 mice significantly increased total GSH levels in the hippocampus. Neither SCH58261, an adenosine A2A receptor antagonist, nor… Expand
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