Caffeine and nicotinamide enhances the aqueous solubility of the antimalarial agent halofantrine.

@article{Lim2000CaffeineAN,
  title={Caffeine and nicotinamide enhances the aqueous solubility of the antimalarial agent halofantrine.},
  author={L. Lim and M. Go},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2000},
  volume={10 1},
  pages={
          17-28
        }
}
  • L. Lim, M. Go
  • Published 2000
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
The aqueous solubility of the antimalarial agent halofantrine in phosphate buffers pH 5.9 and 7.0 (ionic strength 0.08) is increased by the addition of caffeine and nicotinamide. Solubility is increased to a greater extent in the presence of caffeine (12.5-125 mM) than nicotinamide (125 mM -2.0 M). The greatest increase in solubility was observed at pH 5.9 where the basal solubility of halofantrine rose from 0.91 to 435 microM when 125 mM caffeine was added. Phase solubility studies support the… Expand
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