Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles.

@article{Egawa2009CaffeineAA,
  title={Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles.},
  author={Tatsuro Egawa and Taku Hamada and Naoko Kameda and Kouhei Karaike and Xiao Ma and Shinya Masuda and Nobumasa Iwanaka and Tatsuya Hayashi},
  journal={Metabolism: clinical and experimental},
  year={2009},
  volume={58 11},
  pages={1609-17}
}
Caffeine (1,3,7-trimethylxanthine) has been implicated in the regulation of glucose and lipid metabolism including actions such as insulin-independent glucose transport, glucose transporter 4 expression, and fatty acid utilization in skeletal muscle. These effects are similar to the exercise-induced and 5'adenosine monophosphate-activated protein kinase (AMPK)-mediated metabolic changes in skeletal muscle, suggesting that caffeine is involved in the regulation of muscle metabolism through AMPK… CONTINUE READING
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