Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.

@article{Kaster2015CaffeineAT,
  title={Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.},
  author={Manuella Pinto Kaster and Nuno J Machado and Henrique Borges da Silva and Ana Teresa Nunes and Ana Paula Ardais and M. H. M. Santana and Younis Baqi and Christa E. M{\"u}ller and Ana L{\'u}cia S Rodrigues and Lisiane de Oliveira Porci{\'u}ncula and Jiang Fan Chen and {\^A}ngelo R. Tom{\'e} and Paula M. Agostinho and Paula M Canas and Rodrigo A Cunha},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 25},
  pages={7833-8}
}
The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate therapeutic targets because they control aberrant synaptic plasticity and afford neuroprotection. Therefore we tested the ability of A2AR to control the behavioral, electrophysiological, and neurochemical modifications caused by chronic unpredictable stress (CUS), which alters hippocampal circuits, dampens… CONTINUE READING
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