Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.

@article{Nagatomo2008CaffeineAM,
  title={Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.},
  author={Katsuhiro Nagatomo and Yoshihiro Kubo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 45},
  pages={17373-8}
}
Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca(2+)(i) imaging and electrophysiological analyses. These responses to caffeine were confirmed in acutely dissociated dorsal root ganglion sensory neurons from WT mice, which are known to express TRPA1, but were… CONTINUE READING