Caffeine-Induced Activated Glucocorticoid Metabolism in the Hippocampus Causes Hypothalamic-Pituitary-Adrenal Axis Inhibition in Fetal Rats

@inproceedings{Xu2012CaffeineInducedAG,
  title={Caffeine-Induced Activated Glucocorticoid Metabolism in the Hippocampus Causes Hypothalamic-Pituitary-Adrenal Axis Inhibition in Fetal Rats},
  author={Dan Xu and Benjian Zhang and Gai Liang and Jie Ping and H. M. Kou and Xiaojun Li and Jie Xiong and Dongcai Hu and Liaobin Chen and Jacques Magdalou and Hui Wang},
  booktitle={PloS one},
  year={2012}
}
Epidemiological investigations have shown that fetuses with intrauterine growth retardation (IUGR) are susceptible to adult metabolic syndrome. Clinical investigations and experiments have demonstrated that caffeine is a definite inducer of IUGR, as children who ingest caffeine-containing food or drinks are highly susceptible to adult obesity and hypertension. Our goals for this study were to investigate the effect of prenatal caffeine ingestion on the functional development of the fetal… CONTINUE READING