Caffeine: sleep and daytime sleepiness.

@article{Roehrs2008CaffeineSA,
  title={Caffeine: sleep and daytime sleepiness.},
  author={Timothy Roehrs and Thomas Roth},
  journal={Sleep medicine reviews},
  year={2008},
  volume={12 2},
  pages={
          153-62
        }
}
  • T. Roehrs, T. Roth
  • Published 1 April 2008
  • Psychology, Biology
  • Sleep medicine reviews

Tables from this paper

Regular caffeine intake attenuates REM sleep promotion and sleep quality in healthy men
TLDR
There is evidence that regular caffeine intake during daytime weakens circadian sleep promotion when compared to placebo, and the observed caffeine-induced deterioration in the quality of awakening may suggest a potential motive to reinstate caffeine intake after sleep.
Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men
TLDR
Regular daytime caffeine intake affects REM sleep regulation in men, such that it delays circadian REM sleep promotion when compared with placebo, and the observed caffeine-induced deterioration in the quality of awakening may suggest a potential motive to reinstate caffeine intake after sleep.
Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake
TLDR
The typical timing of habitual caffeine intake in humans may not necessarily shift circadian phase nor lead to clear-cut benefits in alertness, and the time-of-day independent effects of caffeine withdrawal suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation.
Wide awake at bedtime? The effects of caffeine on sleep and circadian timing in teenagers - a randomized crossover trial
TLDR
In teenagers, evening caffeine intake of already 80 mg (i.e. ∼8fl oz of common energy drinks) is sufficient to promote alertness at the costs of subsequent sleep, consequently hampering the balanced interplay of sleep-wake regulatory components.
Effects of Caffeine on Skin and Core Temperatures, Alertness, and Recovery Sleep During Circadian Misalignment
TLDR
It is highlighted that sleep disturbances associated with caffeine consumed near the circadian trough of alertness are still present when daytime recovery sleep occurs 5 h or approximately 1 half-life later.
The effect of caffeine abstinence on sleep among habitual caffeine users with poor sleep
TLDR
The data suggest that abstaining from caffeine may not result in long‐term sleep improvement for habitual caffeine users, which contradicts the common sleep health recommendation.
Limited Efficacy of Caffeine and Recovery Costs During and Following 5 Days of Chronic Sleep Restriction
TLDR
Caffeine appears to have limited efficacy for maintaining alertness and wakefulness across 5 days of sleep restriction, and perhaps more importantly, there may be recovery costs associated with caffeine use following conditions of prolonged sleep loss.
Naturalistic Effects of Five Days of Bedtime Caffeine Use on Sleep, Next-Day Cognitive Performance, and Mood.
TLDR
Caffeine disrupted sleep, although when assessing next-day performance, which may have been affected by the presence of residual caffeine, performance appeared better after caffeine compared to placebo, although this was most likely due to prevention of the effects of overnight withdrawal from caffeine rather than representing a net benefit.
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References

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TLDR
The data indicated that caffeine was effective in producing significant metabolic and sleep effects and that those effects were related, consistent with the interpretation that a chronic decrease in sleep efficiency associated with increased physiological arousal, although producing subjective dysphoria, does not produce a physiological sleep debt.
Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction
TLDR
Cognitive performance was found to be affected adversely by acute caffeine withdrawal and, even in the context of alertness lowered by sleep restriction, cognitive performance was not improved by caffeine in the absence of these withdrawal effects, suggesting that there is little benefit to be gained from caffeine consumption.
Circadian preference, sleep and daytime behaviour in adolescence
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The results suggest that circadian preference might be related not only to sleep pattern, but also to other adolescent behaviours, such as attention problems, poor school achievement, more injuries and more emotionally upset than the other chronotype.
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It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
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TLDR
Higher caffeine intake in general was associated with shorter nocturnal sleep duration, increased wake time after sleep onset, and increased daytime sleep, andLimitation of the availability of caffeine to teenagers should be considered.
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TLDR
It is suggested that coffee and caffeine may be used in normal subjects to induce symptoms mimicking those of insomnia and such a tool should promote further understanding of insomnia.
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TLDR
The sleep extension improved daytime sleepiness differentially in the two groups and the degree of improvement was greater in the sleepy subjects than the alert subjects and the pattern of improvement differed between the groups.
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