Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines.

@article{Woziwodzka2011CaffeinePA,
  title={Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines.},
  author={Anna Woziwodzka and Anna Gwizdek-Wiśniewska and Jacek Piosik},
  journal={Bioorganic chemistry},
  year={2011},
  volume={39 1},
  pages={10-7}
}
Methylxanthines (MTX), in particular caffeine (CAF), are known as the most widely consumed alkaloids worldwide. Many accumulated statistical data indicate the protective effect of CAF intake against several types of cancer. One of the possible explanations of this phenomenon is direct non-covalent interaction between CAF and aromatic mutagen/carcinogen molecules through stacking (π-π) complexes formation. Here we demonstrate that CAF and other MTX, pentoxifylline (PTX) and theophylline (TH… CONTINUE READING