Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.

@article{Tolba2013CaffeicAP,
  title={Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.},
  author={Mai F. Tolba and Ahmed M. Esmat and Ahmed M Al-Abd and Samar Saad Eldeen Azab and Amani E. Khalifa and Hisham AM Mosli and S. Z. Abdel-Rahman and Ashraf B Abdel-Naim},
  journal={IUBMB life},
  year={2013},
  volume={65 8},
  pages={716-29}
}
Evidence is growing for the beneficial role of selective estrogen receptor modulators (SERM) in prostate diseases. Caffeic acid phenethyl ester (CAPE) is a promising component of propolis that possesses SERM activity. This study aimed at investigating the modulatory impact of CAPE on docetaxel (DOC) and paclitaxel (PTX) cytotoxicity in prostate cancer cells and exploring the possible underlying mechanisms for this chemomodulation. CAPE significantly increased DOC and PTX potency in PC-3, DU-145… CONTINUE READING

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