Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats.

@article{Albukhari2009CaffeicAP,
  title={Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats.},
  author={Ashwag A Albukhari and Hana M. Gashlan and Hesham Ahmad El-Beshbishy and Ayman Abdel Hamid Nagy and Ashraf B Abdel-Naim},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2009},
  volume={47 7},
  pages={1689-95}
}
Tamoxifen (TAM) is widely used in the treatment and prevention of breast cancer. Adverse effects of TAM include hepatotoxicity. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been used in folk medicine for diverse ailments. In the current study, the protective effects of CAPE against TAM-induced hepatotoxicity in female rats were evaluated. TAM (45 mg/kg/day, i.p., for 10 consecutive days) resulted in an elevation of serum alanine aminotransferase (ALT), aspartate… CONTINUE READING