Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration.

@article{Fontanilla2011CaffeicAP,
  title={Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration.},
  author={Christine V. Fontanilla and Z Ma and Xiaofei Wei and Jens Klotsche and L Zhao and Paul Wisniowski and Richard C. Dodel and Martin R. Farlow and Wolfgang Hermann Oertel and Yansheng Du},
  journal={Neuroscience},
  year={2011},
  volume={188},
  pages={135-41}
}
Parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. The neuroprotective effect of CAPE was associated with marked reductions in inducible nitric oxide synthase (iNOS) and… CONTINUE READING

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