Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model.

@article{Choi2015CaffeicAP,
  title={Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model.},
  author={Jae-Hyeog Choi and Kug-Hwan Roh and Hana Oh and Sol-Ji Park and Sung-min Ha and Mi Seon Kang and Ji-Hyun Lee and So Young Jung and Hyunkeun Song and Jae Wook Yang and Saegwang Park},
  journal={Experimental eye research},
  year={2015},
  volume={134},
  pages={53-62}
}
Experimental autoimmune uveoretinitis (EAU) is an autoimmune disease that models human uveitis. Caffeic acid phenethyl ester (CAPE), a phenolic compound isolated from propolis, possesses anti-inflammatory and immunomodulatory properties. CAPE demonstrates therapeutic potential in several animal disease models through its ability to inhibit NF-κB activity. To evaluate these therapeutic effects in EAU, we administered CAPE in a model of EAU that develops after immunization with interphotoreceptor… CONTINUE READING