Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.

@article{Jin2015CaffeicAP,
  title={Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.},
  author={Liu-Gen Jin and Jian-jun Chu and Qing-Feng Pang and Fu-zheng Zhang and Gang Wu and Le-yuan Zhou and Xiao-jun Zhang and Chun-gen Xing},
  journal={Environmental toxicology and pharmacology},
  year={2015},
  volume={40 1},
  pages={156-63}
}
Caffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the free radicals. This study aimed to investigate the radioprotective effects of CAPE on X-ray irradiation induced intestinal injury in rats. Rats were intragastrically administered with 10 μmol/kg/d CAPE for 7 consecutive days before exposing them to a single dose of X-ray irradiation (9Gy) to abdomen. Rats were sacrificed 72 h after exposure to radiation. We found that pretreatment with CAPE effectively… CONTINUE READING