Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.

@article{Dong2011CaffeicA3,
  title={Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.},
  author={Anliang Dong and Yuanzhang Fang and Li Zhong Zhang and Juan Xie and Xian Wu and Lipeng Zhang and Xiaoyuan Lian and Yihua Chen and Jian Luo and Mingyao Liu},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={339 1},
  pages={238-47}
}
Compared with traditional cytotoxic cancer therapy, therapy-induced cancer cell senescence attracts much interest because it is similarly effective, has fewer side effects, and is more efficiently cleared by immune cells. In this study, we demonstrate that unlike caffeic acid phenethyl ester, caffeic acid 3,4-dihydroxy-phenethyl ester (CADPE), which is isolated from the medicinal plants Sarcandra glabra and Teucrium pilosum, inhibits human cancer cell growth and colony formation by inducing… CONTINUE READING
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