Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling

@inproceedings{Kuo2013CaffeicAP,
  title={Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling},
  author={Ying-Yu Kuo and Hui-Ping Lin and Chieh Huo and Liang-Cheng Su and Jonathan Y Yang and Ping-Hsuan Hsiao and Hung-Che Chiang and Chi-Jung Chung and Horng-Dar Wang and J. Y. Chang and Ya-Wen Chen and Chih-pin Chuu},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cells. Treatment with CAPE decreased protein abundance of Akt, Akt1, Akt2, Akt3, phospho-Akt Ser473… CONTINUE READING
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