Caffeic Acid Inhibits Chronic UVB-Induced Cellular Proliferation Through JAK-STAT3 Signaling in Mouse Skin.

@article{Agilan2016CaffeicAI,
  title={Caffeic Acid Inhibits Chronic UVB-Induced Cellular Proliferation Through JAK-STAT3 Signaling in Mouse Skin.},
  author={Balupillai Agilan and Nagarajan Rajendra Prasad and Govindasamy Kanimozhi and Ramasamy Karthikeyan and Muthusamy Ganesan and Shanmugam Mohana and D. Velmurugan and Dhanapalan Ananthakrishnan},
  journal={Photochemistry and photobiology},
  year={2016},
  volume={92 3},
  pages={467-74}
}
Signal transducers and activators of transcription 3 (STAT3) play a critical role in inflammation, proliferation and carcinogenesis. Inhibition of JAK-STAT3 signaling is proved to be a novel target for prevention of UVB-induced skin carcinogenesis. In this study, chronic UVB irradiation (180 mJ cm(-2) ; weekly thrice for 30 weeks) induces the expression of IL-10 and JAK1 that eventually activates the STAT3 which leads to the transcription of proliferative and antiapoptotic markers such as PCNA… CONTINUE READING