Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice.

Abstract

Daily coffee consumption is inversely associated with risk of type-2 diabetes (T2D). Cafestol, a bioactive substance in coffee, increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. We hypothesized that cafestol can postpone development of T2D in KKAy mice. Forty-seven male KKAy mice were randomized to consume chow supplemented daily with either 1.1 (high), 0.4 (low), or 0 (control) mg of cafestol for 10 weeks. We collected blood samples for fasting glucose, glucagon, and insulin as well as liver, muscle, and fat tissues for gene expression analysis. We isolated islets of Langerhans and measured insulin secretory capacity. After 10 weeks of intervention, fasting plasma glucose was 28-30% lower in cafestol groups compared with the control group (p < 0.01). Fasting glucagon was 20% lower and insulin sensitivity improved by 42% in the high-cafestol group (p < 0.05). Cafestol increased insulin secretion from isolated islets by 75-87% compared to the control group (p < 0.001). Our results show that cafestol possesses antidiabetic properties in KKAy mice. Consequently, cafestol may contribute to the reduced risk of developing T2D in coffee consumers and has a potential role as an antidiabetic drug.

DOI: 10.1021/acs.jnatprod.7b00395

Cite this paper

@article{Mellbye2017CafestolAB, title={Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice.}, author={Fredrik Brustad Mellbye and Per Bendix Jeppesen and Pedram Shokouh and Christoffer Laustsen and K. Hermansen and S\oren Schou Gregersen}, journal={Journal of natural products}, year={2017}, volume={80 8}, pages={2353-2359} }