Caesalpinia sappan: A promising natural source of antimicrobial agent for inhibition of cariogenic bacteria.

  title={Caesalpinia sappan: A promising natural source of antimicrobial agent for inhibition of cariogenic bacteria.},
  author={Rinrampai Puttipan and Sunee Chansakaow and Sakornrat Khongkhunthian and Siriporn Okonogi},
  journal={Drug discoveries \& therapeutics},
  volume={12 4},
From the previous findings, the ethanolic fractionated extract of Caesalpinia sappan (F-EtOH) has high activity against Streptococcus mutans, the most severe cariogenic bacteria. The present study was aimed to isolate and identify the active compound of F-EtOH and compare its inhibitory activity against the biofilm of S. mutans as well as the cytotoxicity to oral fibroblast cells with F-EtOH. Compound isolation was done by column chromatography. The active compound was identified using liquid… Expand
Effect of Ethanolic Caesalpinia sappan Fraction on In Vitro Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus
In vitro antiviral activity against PRRSV of a semi-purified fraction of ethanolic CS crude extract using preparative high-performance liquid chromatography is focused on and useful information is provided for further study to effectively develop the CS bioactive antiviral compounds againstPRRSV as a feed additive or veterinary drug in the pig industry. Expand
Natural dye from Caesalpinia sappan L. heartwood for eco-friendly coloring of recycled paper based packing material and its in silico toxicity analysis
The extracted dye had a good photostability and able to make imprints on recycled paper bags and a significant inhibition of bacterial growth was observed at a higher dye concentration of 100 μg mL−1 against P. aeruginosa which was higher than the standard antibiotics. Expand


In vitro antimicrobial activity of Caesalpinia sappan L.
Abstract Objective To identify the antimicrobial activity of Caesalpinia sappan (C. sappan). Methods Antimicrobial activity of C. sappan was tested with various solvent ethanol, aqueous and petroleumExpand
Effects of Caesalpinia sappan on pathogenic bacteria causing dental caries and gingivitis.
F-EtOH is the promising extract of C. sappan for inhibiting oral pathogenic bacteria and appropriate as natural antiseptic for further develop of oral hygiene products. Expand
The antibacterial principle of Caesalpina sappan
  • H. Xu, S. Lee
  • Biology, Medicine
  • Phytotherapy research : PTR
  • 2004
Brasilin is an antibacterial principle from Caesalpina sappan and it has the potential to be developed into an antibiotic. Expand
Brazilin from Caesalpinia sappan wood as an antiacne agent
In screening experiments for antiacne activity, methanolic and 50% ethanolic extracts of Caesalpinia sappan wood showed the most potent activity out of 28 species of plants extracts. These extractsExpand
The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors of Streptococcus mutans
The findings suggest that EGCg is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Expand
Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.
Evidence is provided for the efficacy of the traditional use of C. sappan as an anti- inflammatory remedy and the anti-inflammatory activity of diverse compounds from C.sappan may be of interest for the development of complementary and alternative treatment strategies. Expand
Screening for antibacterial and antibiofilm activity in Thai medicinal plant extracts against oral microorganisms
The major constituent of P. betle extract was 4-chromanol, which responded for antibacteria and antibiofilm against oral pathogens, which suggests that the ethanol P.betle leaves extract may be used for preventing oral diseases. Expand
Comparative study of in vitro antibacterial activity of leaves, bark, heart wood and seed extracts of Caesalpinia sappan L.
ABSTRACT Objective To evaluate and compare the maximum antimicrobial activity by screening different parts of Caesalpinia sappan L. extracted in different solvents against Salmonella ebony (MTCCExpand
In vitro study for inhibition of NO production about constituents of Sappan Lignum.
The screening found that the methanolic extract of Sappan Lignum showed strong activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production by macrophages in vitro, and Brazilin inhibited inducible NO gene, but strong activities were not observed for protosappanins A, B and C. Expand
Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review.
CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats, and Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food, beverage, cosmetics and pharmaceutical industries. Expand