Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents.

@article{Srinivasan2013CaeruleinPF,
  title={Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents.},
  author={Dinesh Kumar Srinivasan and Milena Mechkarska and Yasser Hassan Atef Abdel-Wahab and Peter Raymond Flatt and J Michael Conlon},
  journal={Biochimie},
  year={2013},
  volume={95 2},
  pages={429-35}
}
Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line. These peptides were purified to near homogeneity and structural characterization showed that they belong to the magainin (2 peptides), peptide glycine-leucine-amide (PGLa) (1 peptide), xenopsin precursor fragment (1 peptide), and caerulein… CONTINUE READING

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