Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva

@article{Minniti2004CaenorhabditisES,
  title={Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva},
  author={Alicia N. Minniti and Mariana Labarca and Claudia Hurtado and Enrique Brandan},
  journal={Journal of Cell Science},
  year={2004},
  volume={117},
  pages={5179 - 5190}
}
In Caenorhabditis elegans, the identification of many enzymes involved in the synthesis and modification of glycosaminoglycans (GAGs), essential components of proteoglycans, has attained special attention in recent years. [] Key Result In the sdn-1 (ok449) deletion mutant allele we observed the lack of one species, which corresponds to a 50 kDa product after heparitinase treatment. The expression of sdn-1 mRNA and sequencing revealed that sdn-1 (ok449) deletion mutants lack two glycosylation sites.
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TLDR
A new level of knowledge is developed for the whole syndecan family by combining molecular phylogeny of Syndecan protein sequences with analysis of the genomic contexts of syndecans genes in multiple vertebrate organisms.
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