Caenorhabditis elegans senses protons through amphid chemosensory neurons: proton signals elicit avoidance behavior

@article{Sambongi2000CaenorhabditisES,
  title={Caenorhabditis elegans senses protons through amphid chemosensory neurons: proton signals elicit avoidance behavior},
  author={Y. Sambongi and K. Takeda and T. Wakabayashi and I. Ueda and Y. Wada and M. Futai},
  journal={NeuroReport},
  year={2000},
  volume={11},
  pages={2229–2232}
}
Acidic pH is known to cause pain sensation through nociceptive neurons as well as taste transduction in mammals. Caenorhabditis elegans avoids an acidic environment (pH lower than ∼ 4.0) formed by organic or inorganic acids. This avoidance behavior was dependent on multiple amphid chemo-sensory neurons, and inhibited by a mutation of capsaicin receptor homologue, and by the addition of amiloride and ruthenium red (inhibitors of proton-gated Na+ channels and capsaicin receptors, respectively… Expand
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