Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1

@inproceedings{Kang2013CaenorhabditisER,
  title={Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1},
  author={Yuan-Lin Kang and John K Yochem and Leslie David Bell and Erika B. Sorensen and Lihsia Chen and Sean D Conner},
  booktitle={Molecular biology of the cell},
  year={2013}
}
Low-density lipoprotein receptor (LDLR) internalization clears cholesterol-laden LDL particles from circulation in humans. Defects in clathrin-dependent LDLR endocytosis promote elevated serum cholesterol levels and can lead to atherosclerosis. However, our understanding of the mechanisms that control LDLR uptake remains incomplete. To identify factors critical to LDLR uptake, we pursued a genome-wide RNA interference screen using Caenorhabditis elegans LRP-1/megalin as a model for LDLR… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

C. elegans as a model for membrane traffic.

  • WormBook : the online review of C. elegans biology
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

of Caenorhabditis elegans

C Chen, X Zhuang
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL