Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

@article{Beitel1990CaenorhabditisER,
  title={Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction},
  author={Greg J. Beitel and S. G. Clark and H Robert Horvitz},
  journal={Nature},
  year={1990},
  volume={348},
  pages={503-509}
}
The let-60 gene, an essential ras gene of the nematode Caenorhabditis elegans, acts as a switch in the inductive signalling pathway that initiates vulva formation. Recessive let-60 mutations that cause a vulvaless phenotype prevent let-60 function in response to the inductive signal. These mutations are clustered and define regions necessary either for the… CONTINUE READING

Topic