Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium.

@article{Jiang2009CaenorhabditisEM,
  title={Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium.},
  author={George C-T Jiang and Sam Howard Hughes and Stephen R. St{\"u}rzenbaum and Lars G Evje and Tore Syversen and Michael Aschner},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={111 2},
  pages={
          345-54
        }
}
Depleted uranium (DU) is a dense and heavy metal used in armor, ammunition, radiation shielding, and counterbalances. The military usage has led to growing public concern regarding the health effects of DU. In this study, we used the nematode, Caenorhabditis elegans, to evaluate the toxicity of DU and its effects in knockout strains of metallothioneins (MTs), which are small thiol-rich proteins that have numerous functions, such as metal sequestration, transport, and detoxification. We examined… CONTINUE READING

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