Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

@article{Hengartner1992CaenorhabditisEG,
  title={Caenorhabditis elegans gene ced-9 protects cells from programmed cell death},
  author={Michael O. Hengartner and Ronald Ellis and Robert Horvitz},
  journal={Nature},
  year={1992},
  volume={356},
  pages={494-499}
}
The gene ced-9 of the nematode Caenorhabditis elegansacts to protect cells from programmed cell death. A mutation that abnormally activatesced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the… CONTINUE READING
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