Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase

@article{Thacker2006CaenorhabditisED,
  title={Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase},
  author={Colin Thacker and Jonathan A. Sheps and A. M. Rose},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={1193-1204}
}
Genetic analysis of the nematode Caenorhabditis elegans reveals that all dpy-5 alleles are dominant suppressors of bli-4 blistering. Molecular cloning of dpy-5 establishes that it encodes a cuticle procollagen, defects in which are responsible for the short-body, dumpy phenotype. The null mutation, e907 removes the entire coding region, whereas the dpy-5 reference allele, e61, contains a nonsense substitution. RT-PCR analysis and a dpy-5::gfp fusion show that dpy-5 is expressed only in… CONTINUE READING
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